Within the intricate biochemical networks that sustain cellular vitality, few molecules occupy as central a position as nicotinamide adenine dinucleotide (NAD+). Although NAD+ itself is not a peptide, contemporary biochemical discourse increasingly refers to “NAD+ peptide systems” when describing peptide-regulated enzymes and signaling pathways whose catalytic or regulatory activity depends upon intracellular NAD+ availability. In this context, NAD+ is believed to function as a redox cofactor, a substrate for post-translational modifications, and a metabolic signal integrator. The peptide components of NAD+-dependent systems—most prominently the sirtuin family and poly(ADP-ribose) polymerases—form a regulatory architecture that research indicates may coordinate genomic stability, energy metabolism, circadian rhythm alignment, and adaptive stress responses within the organism.

HUD is announcing that homelessness-related service providers across the nation can expect the 2026 Continuum of Care (CoC) Notice of Funding Opportunity (NOFO) to be published by June 1, 2026. Further, applicants can expect awards to be made by December 1, 2026. The CoC Program is a national competition designed to promote community-wide efforts to reduce homelessness and optimize self-sufficiency.

As the number of people living on our streets remains at crisis levels, HUD is committed to reforming its homelessness programs. The status quo of “housing first” and “harm reduction” has failed at great cost to those suffering on our streets and to working American taxpayers.